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Applications of chlorine dioxide in medicine

30 - Apr - 2026

Used in skin protectants, cleansers, and disinfectants

Chlorine dioxide's direct application to the human body began with skin diseases, and it has obtained several patents abroad: For skin cleansing, there are Bunyan's US. Pat. 4035483 and Alliger's US. Pat. 4737307; for treating skin lesions and acne, there is Alliger's US. Pat. 4084747; and for treating herpes and fungal infections, there is Krossr's US. Pat. 4956184. These patents have achieved good results in treating scabies, psoriasis, eczema, dandruff, hemorrhoids, varicose ulcers, wounds, acne, genital herpes, leg ulcers, and even in treating colon, muscle, bone, and tendon injuries and infections, preventing cross-infection and co-infections.

Generally, it is used in sprays, ointments, or washes at a concentration below 200 mg/L ClO₂ , or formulated as an ointment (US. Pat. 6114398), with the ointment containing 1000 mg/L chlorine dioxide. In some cases, other oral antibiotics are required, such as detoxifying and blood-activating herbs from traditional Chinese medicine. Combining these with topical ClO₂ can enhance the effect, as in cases of psoriasis.

Used for gynecological disinfection

For vaginitis, vaginal odor, endometriosis, vulvar dryness, leukoplakia of the mucous membranes caused by bacterial and yeast infections, and tinea manuum, 50mg/L ClO₂ can be used for direct rinsing, wiping, or application. ClO₂ can be used for environmental disinfection in maternity wards and nurseries .

Ratcliff applied ClO₂ to treat gynecological conditions such as vaginal infections, endometriosis, and vulvar dryness. He pointed out that any bodily orifice infected with bacteria or yeast, or with conditions like leukoplakia or tinea manuum, can be treated with ClO₂. One of the most interesting examples is a female secretary suffering from vaginitis and unbearable itching. She tried using a mouthwash containing ClO₂ to rinse her vagina and applying a wet compress to her vulva. In less than three days, a miracle occurred: the vaginitis was cured. This is because the vaginal mucosa is similar to the oral cavity; bacteria can break down proteins, producing sulfides (such as methanethiol) that cause a foul odor. Therefore, ClO₂ can be used to treat vaginitis.

Used for ophthalmic disinfection and treatment of eye diseases.

Contact lenses were originally disinfected with borax-based agents, then with hydrogen peroxide, and are now gradually being disinfected with ClO₂ , a method for which patents have been obtained (US. Pat. 4997626, US. Pat. 5276673, US. Pat. 5078908, and US. Pat. 5129999, etc.). Because trace amounts of ClO₂ are non-toxic and harmless to the eyes and can be tolerated, Ripley applies ClO₂ directly to the eyes. Previously used ophthalmic medications had low efficacy and short duration of action. Ripley utilizes the stability of solid ClO₂ , packaging it in an opaque bottle with polyethylene microbeads containing transition metals such as palladium or platinum in the neck. When used, the bottle is inverted; as the solid ClO₂ solution flows through the porous polyethylene microbeads, it is catalyzed and activated by palladium into ClO₂ monomers . This isotonic, neutral solution containing 5 mg/L of ClO₂ monomer can be used to treat eye diseases. For example, for conjunctivitis, three drops three times a day usually cures the condition in 3-5 days. Neutral, isotonic saline solution at 3-5 mg/L can be directly used to treat conjunctivitis, boils, and pink eye. Using this isotonic, neutral, low-concentration ClO₂ monomer solution instead of sterile saline is of course more effective. It can be used as an irrigation solution to remove blood clots, tissue fragments, and other debris to facilitate surgery, while also having bactericidal, disinfectant, and postoperative infection prevention effects. This irrigation solution can also be used in other surgical procedures.

Used for surgical disinfection and wound rinsing.

It can replace povidone-iodine, antibiotic saline, and ordinary saline as a disinfectant and wound rinsing solution to prevent postoperative infection. The concentration should be 5-20 mg/L ClO isotonic neutral solution.